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Seizure as a presenting manifestation of Wernicke's encephalopathy induced by hyperemesis gravidarum
Ritwik Ghosh1, Arpan Mandal1, Devlina Roy2, Subhankar Chatterjee3, Mrinal Kanti Ghosh4, Souvik Dubey5, Durjoy Lahiri5, Josef Finsterer6, Biman Kanti Ray5
1 Department of General Medicine, Burdwan Medical College & Hospital, Burdwan, West Bengal, India
2 Department of General Medicine-Infectious Disease and Beleghata General Hospital, Kolkata, West Bengal, India
3 Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
4 Department of Radiodiagnosis, Burdwan Medical College & Hospital, Burdwan, West Bengal, India
5 Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Postgraduate Medical Education & Research and SSKM Hospital, Kolkata, West Bengal, India
6 Department of Neurology, Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria
Correspondence Address:
Dr. Biman Kanti Ray
Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Postgraduate Medical Education and Research & SSKM Hospital, Kolkata, West Bengal
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jfmpc.jfmpc_1466_20
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Wernicke's encephalopathy (WE) is an acute neurological condition characterized by the triad of ophthalmoparesis with nystagmus, ataxia, and global confusion. WE is a life-threatening illness caused by thiamine deficiency, primarily affecting the peripheral and central nervous systems. Thiamine deficiency is predominantly associated with chronic alcoholism, but various other causes have also been reported, including severe malnutrition, prolonged parenteral nutrition, malignancies, immunodeficiency syndromes, liver disease, hyperthyroidism and severe anorexia nervosa, and hyperemesis gravidarum. We, hereby, report a unique case of WE induced by hyperemesis gravidarum that presented in mid-trimester of pregnancy in a rather extremely unusual way with focal seizures and secondary generalization but fortunately ended up with a good feto-maternal outcome.
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