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Year : 2020  |  Volume : 9  |  Issue : 9  |  Page : 5046-5048

Insulin autoimmune syndrome: A rare cause of hypoglycemia

Departments of Pathology and Family Medicine, LLH Hospital Al Musaffah, Abudhabi, UAE

Correspondence Address:
Dr. Tejas M Maheshwari
LLH Hospital AL Musaffah, PO BOX 92313, Abudhabi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfmpc.jfmpc_319_20

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Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinemic hypoglycemia. It is due to autoantibodies to endogenous insulin in person who has never been sensitized to insulin by injections. IAS is a third leading cause of spontaneous hypoglycemia in Japan and it is increasingly being recognized worldwide in non-Asian population. However, we report a case of IAS in Asian male. A certain class of medication called sulfhydryl compounds have been shown to sometimes cause IAS. Recently a compound called alpha lipoic acid (ALA) has been associated with an increased risk of developing IAS. ALA is sometimes used for dieting purposes. We report a case of 36-year-old Indian male presented with symptoms of dizziness and feeling of hunger with sweating, noted to have low blood sugars on multiple occasions. There is a definite history of ALA compound intake as dietary supplements with multivitamins. Subsequently, he was diagnosed as a case of recurrent hypoglycemia from IAS due to ALA intake and managed accordingly.

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