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Year : 2019  |  Volume : 8  |  Issue : 11  |  Page : 3480-3486

Red complex: Polymicrobial conglomerate in oral flora: A review

1 Department of Periodontics, Institute of Dental Sciences, SOA Deemed to University, Bhubaneswar, Odisha, India
2 Department of Prosthodontics, Rajasthan Dental College and Hospital, Jaipur, Rajasthan, India
3 Department of Conservative Dentistry and Endodontics, P.S.M Dental College and Research Centre, Akkikavu, Thrissur, Kerala, India
4 Department of Oral Medicine and Radiology, Government Dental College, Kottyam, Kerala, India
5 Department of Oral and Maxillofacial Pathology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India
6 Department of Orthodontics, A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka, India
7 Department of Periodontics, BRS Dental College and Hospital, Haryana, India

Correspondence Address:
Dr. K Saidath
Department of Orthodontics, A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfmpc.jfmpc_759_19

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Oral diseases are the complex host responses composed of a broad array of inflammatory cells, and cytokines, chemokines, and mediators derived from the cells resident in the gingival tissues, as well as from the emigrating inflammatory cells. A chronic polymicrobial challenge to the local host tissues triggers this response, which under certain circumstances, and in a subset of the population, leads to the progressing soft and hard tissue destruction that characterizes periodontitis. The red complex has been proposed as a pathogenic consortium, consisting of P. gingivalis, T. denticola, and T. forsythia. This review has attempted to examine the virulence potential and determinants of these commensal opportunists.

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