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Year : 2019  |  Volume : 8  |  Issue : 10  |  Page : 3120-3124

Association of leukemia and mitochondrial diseases—A review

1 Department of Prosthodontics, J.C.D Dental College, Sirsa, Haryana, India
2 Department of Oral and Maxillofacial Pathology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India
3 Department of Prosthodontics, Shaheed Kartar Singh Sarabha Dental College and Hospital, Sarabha, Ludhiana, Punjab, India
4 Department of Public Health Dentistry, Shaheed Kartar Singh Sarabha Dental College and Hospital, Sarabha, Ludhiana, Punjab, India
5 Department of Oral Medicine, Private Practitioner, New Delhi, India

Correspondence Address:
Dr. Vivek Rana
Department of Oral Medicine, Private Practitioner, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfmpc.jfmpc_679_19

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Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients.

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