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Year : 2013  |  Volume : 2  |  Issue : 4  |  Page : 399-401

Reprogramming of gastric motility with "pulse therapy" (metoclopramide and erythromycin) in severe gastroparesis

Department of Medicine, Division of Gastroenterology, University Hospital, Rutgers - New Jersey Medical School, Newark, NJ, USA

Correspondence Address:
Shamik Shah
Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers - New Jersey Medical School, 185 South Orange Avenue, MSB H-538, Newark, New Jersey 07103
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2249-4863.123944

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Gastroparesis is a very common condition, however many times it becomes difficult to manage even after long-term treatment due to multiple etiologies or improper therapy. Patients with severe gastroparesis are considered candidates for gastric electrical stimulants. The "Pulse Therapy" using metoclopramide and erythromycin to reprogram gastric motility can delay or even avoid the need for gastric electrical stimulants. This case report focuses on a patient with severe gastroparesis, who was considered for a gastric pacemaker implantation and was instead treated successfully with "Pulse Therapy." As a part of this regimen, he was given metoclopramide continuously for 3 months along with pulses of erythromycin for 10 days a month for 3 months. Patient recovered dramatically that he no longer remained a candidate for gastric pacemaker implantation. This case study emphasizes on how the proper use of prokinetic agents based on symptoms and gastric emptying study can reprogram the stomach motility in these patients with severe gastroparesis.

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